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目的观察人工气道建立方式对大鼠心跳骤停模型自主循环恢复后呼吸功能、存活率的影响及改良经口气管插管法的可行性。方法建立窒息法大鼠心跳骤停模型;30只SD大鼠随机分成经口气管插管组(n=15)和气管切开插管组(n=15)两组。观察复苏后大鼠在机械通气与自主呼吸状况下动脉血气值的变化,比较复苏后6、24、72h生存率。结果经口气管插管组在机械通气与自主呼吸状态下的pH值比较,差异无统计学意义(P>0.05),而气管切开组在机械通气与自主呼吸状态下的pH、PaCO2比较,差异均有高度统计学意义(均P<0.001);同期两组间pH、Pa-CO2、PaO2比较,差异均有高度统计学意义(均P<0.001);气管切开组6、24h存活率有明显下降趋势,72h存活率比较差异有统计学意义(P<0.05)。结论对于观察时间长、需要脱机或撤除人工气道的大鼠心跳骤停模型,经口气管插管法建立人工气道优于气管切开插管法;且改良经口气管插管法是值得推荐的一种大鼠气管插管方法。
Objective To observe the effect of artificial airway establishment on respiratory function and survival rate after spontaneous circulation recovery in rat cardiac arrest model and to improve the feasibility of orotracheal intubation. Methods A rat model of cardiac arrest was established by asphyxial injection. Thirty SD rats were randomly divided into two groups: the endotracheal intubation group (n = 15) and the tracheotomy catheter group (n = 15). After resuscitation, the changes of arterial blood gases in mechanical ventilation and spontaneous breathing were observed. The survival rates at 6, 24 and 72 hours after resuscitation were compared. Results There was no significant difference in pH value between mechanical ventilation and spontaneous respiration in orotracheal intubation group (P> 0.05). Compared with pH and PaCO2 in mechanical ventilation and spontaneous breathing, (P <0.001). There were significant differences in pH, Pa-CO2 and PaO2 between the two groups during the same period (all P <0.001). The survival rates at 6 and 24 h after tracheotomy There was a significant downward trend, 72h survival rate difference was statistically significant (P <0.05). Conclusion For the observation of a long time, need to off-line or removal of artificial airway in rat cardiac arrest model, the establishment of artificial airway by tracheal intubation is better than tracheotomy intubation; and improved orotracheal intubation is A recommended rat tracheal intubation method.