目的通过检测不同病程支气管哮喘患者CC16蛋白的含量,了解CC16蛋白含量变化在支气管哮喘的诊断治疗中的作用。方法双抗体夹心ELISA法。结果正常对照组CC16蛋白含量均值为20.1ng/ml,哮喘病程>5年,患者CC16蛋白含量均值为4.30ng/ml,哮喘病程<5年,患者CC16蛋白含量均值为7.38ng/ml,两组差异有统计学意义。结论随着病程的迁延,CC16蛋白水平明显降低。 Objective To detect the content of CC16 in bronchial asthma patients with different course of disease and to understand the role of CC16 protein in the diagnosis and treatment of bronchial asthma. Methods Double antibody sandwich ELISA. Results The average CC16 protein content of normal control group was 20.1ng / ml and the duration of asthma was> 5 years. The average CC16 protein content was 4.30ng / ml and the duration of asthma was less than 5 years. The mean CC16 protein content was 7.38ng / ml in both groups The difference was statistically significant. Conclusion The CC16 protein level is obviously decreased with the prolongation of the course of disease.