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心脏兴奋刺激来源于窦房结(sinoatrial node,SAN),并经结间束传导至房室结(atrioventrieular node,AVN),通过房室结纤维传导至心室浦氏纤维。心脏兴奋起源、传导等障碍是形成心律失常的基础。研究发现在心脏起搏中,有一种在超极化时激活,受环核苷酸调控的离子通道,一般称作超极化激
The excitatory stimulation of the heart originates from the sinoatrial node (SAN) and is transmitted to the atrioventrieular node (AVN) via the intercavity tract and to the ventricular fibula via the AV node fibers. The origin of cardiac excitability, conduction and other obstacles form the basis of arrhythmia. It has been found in cardiac pacing that there is an ion channel that is activated during hyperpolarization and is regulated by cyclic nucleotides, commonly referred to as hyperpolarization