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目的探讨埃索美拉唑并改变生活方式治疗胃食管反流病的效果。方法将经胃镜检查证实的96例糜烂性食管炎患者,采用随机、双盲法分成埃索美拉唑并改变生活方式组和未改变生活方式组,每组48例。两组均予埃索美拉唑20mg,每日2次口服,并在此基础上设立有无生活方式改变组,于治疗8周后观察症状的缓解情况,同时复查胃镜观察治疗效果。结果两组治疗8周后症状改善总有效率分别为94.00%、85.00%(P>0.05);内镜下愈合率分别为92.00%、77.00%(P<0.05),差异有非常显著的统计学意义。结论改变生活方式对治疗胃食管反流病有效。
Objective To investigate the effect of esomeprazole and lifestyle changes on gastroesophageal reflux disease. Methods 96 cases of esophagitis esophagitis confirmed by gastroscopy were divided into esomeprazole by randomized, double-blind method and changed the lifestyle group and the unaltered lifestyle group, 48 cases in each group. Both groups were given esomeprazole 20mg, 2 times a day orally, and on this basis, with or without lifestyle changes in the group to observe the relief of symptoms after 8 weeks of treatment, while reviewing endoscopy treatment effect. Results The total effective rates of two groups were 94.00% and 85.00% respectively after 8 weeks of treatment (P> 0.05). The healing rates of endoscopy were 92.00% and 77.00% respectively (P <0.05), the difference was statistically significant significance. Conclusion Changing life style is effective in treating gastroesophageal reflux disease.