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目的了解GLP-1受体激动剂超说明书用药情况,促进临床合理用药。方法采用回顾性调查法,抽取内分泌科2015年12月3日—2016年12月14日使用过GLP-1受体激动剂进行治疗的住院病例,按照药品说明书,判断其超说明书用药情况,对超说明书用药进行分类和统计,并评价其合理性。结果共调查内分泌科住院患者51例,有97例次存在超说明书用药情况,其中超适应证47例次(48.45%),主要表现在联合用药方面,另有50例次(51.55%)属于用法用量超说明书。结论 GLP-1受体激动剂在临床超说明书使用的现象较普遍,某些有其合理性和必要性,但也有不合理用药情况,临床需引起高度重视。
Objective To understand the use of GLP-1 receptor agonist in super instruction manual to promote clinical rational use of drugs. Methods The retrospective investigation method was used to extract endocrine department from Dec. 3, 2015 to Dec. 14, 2016. In-hospital cases treated with GLP-1 receptor agonist were determined according to the drug instruction manual, Super manual medication classification and statistics, and evaluate its rationality. Results A total of 51 inpatients with endocrine disease were investigated. Of the 97 cases, there were over-instruction drug use cases, of which 47 cases were super-indications (48.45%), mainly in combination therapy and another 50 cases (51.55%) were used Super usage instructions. Conclusion GLP-1 receptor agonists are commonly used in clinical super-instructions, some of them have their rationality and necessity, but there are also unreasonable drug use cases, and clinical need to pay great attention.