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采用 HPLC-荧光检测法,对八名先后口服氧氟沙星胶囊剂和片剂进行交叉自身对照的健康志愿者进行了血药浓度测定,并对其药代动力学参数及生物利用度进行了计算,结果氧氟沙星胶囊剂和片剂的主要药动学参数分别为 Cmax4.75±0.53和4.39±0.93mg/L,Tmax1.33±0.45h 和1.59±0.66h AUC_42.68±6.41mg/L.h和38.63±6.38mg/L.h,经统计学处理各参数两组间均无显著差异(P>0.05),氧氟沙星胶囊剂对片剂的相对生物利用度为113.63±28.89%。
Using HPLC-fluorescence detection method, eight volunteers who cross self-controlled oral administration of ofloxacin capsules and tablets were tested for plasma concentration, and their pharmacokinetic parameters and bioavailability were determined Calculated, the main pharmacokinetic parameters of ofloxacin capsules and tablets were Cmax4.75 ± 0.53 and 4.39 ± 0.93mg / L, Tmax1.33 ± 0.45h and 1.59 ± 0.66h AUC_42.68 ± 6.41mg / Lh and 38.63 ± 6.38mg / Lh respectively. There was no significant difference between the two groups (P> 0.05). The relative bioavailability of ofloxacin capsules to tablets was 113.63 ± 28.89%.