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采用免疫组化ABC法对34例有随访资料的肾细胞癌组织标本进行P~(53)表达的研究,结果发现突变型P~(53)癌蛋白的高表达阳性率为35.5％,而正常肾组织均为阴性。提示P~(53)蛋白高表达可能成为肾细胞癌标志之一。P~(53)癌蛋白表达阴性、阳性患者的5年存活率分别为69.6％、26.6％,两组比较无显著性差异(P>0.25)。提示突变型P~(53)蛋白表达可能与肾细胞癌的预后无关.
Immunohistochemical ABC method was used to detect the expression of P53 in 34 cases of renal cell carcinoma with follow-up data. The positive expression rate of P53 was 35.5% Renal tissues were negative. Tip P ~ (53) protein expression may be one of the signs of renal cell carcinoma. The 5-year survival rates of patients with negative P53 protein were 69.6% and 26.6%, respectively. There was no significant difference between the two groups (P> 0.25). The results suggest that the expression of mutant P53 protein may not be related to the prognosis of renal cell carcinoma.