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成人T细胞白血病(ATL)为高月等所发现,日本西南部出生者多见。其病因由三好等通过患者淋巴细胞和脐血淋巴细胞混合培养所建立的细胞株中在电镜下见到病毒(HTLV-1)的同时,患者血清与该细胞株产生的抗原蛋白发生反应而确立。从HTLV-1携带者调查结果表明,其感染具有家族性,夫妻间感染主要是丈夫传染给妻子,因精液中存在HILV-1感染细胞。同时还证明可发生母儿间感染。 有关HTLV-1母儿间感染途径尚不明确。HTLV-1是逆转录病毒,其基因组可通过逆转录转变为双链DNA,整合到宿主基因中。从理论上,此病毒不会以游离状态存在于体内,因此极少在血中
Adult T-cell leukemia (ATL) was found in the high moon, etc. Birth in southwestern Japan more common. The etiology was confirmed by electron microscopy (HTLV-1) in a cell line established by Miyoshi et al. Through mixed culture of patient lymphocytes and cord blood lymphocytes, while the patient serum reacted with the antigen protein produced by the cell line . From the HTLV-1 carriers survey results show that the infection has a familial, husband and wife infection between husband and wife is mainly transmitted to his wife, because of semen HILV-1 infected cells. Also proved that maternal and child infections can occur. The route of infection between mother and child HTLV-1 is not yet clear. HTLV-1 is a retrovirus whose genome can be converted into double-stranded DNA by reverse transcription into the host gene. In theory, this virus does not exist in the body in free form, so rarely in the blood