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目的应用组织芯片技术研究病毒感染与小儿胆道闭锁的关系。方法利用组织芯片技术检测42例胆道闭锁和5例对照组患者肝脏组织中的巨细胞病毒(CMV)和EB病毒(EBV)感染情况。结果在42例胆道闭锁患者肝脏组织中,其中CMV阳性26例(61.9%),EBV阳性3例(7.14%),对照组5例中均未检测到以上病毒的存在。结论胆道闭锁与病毒感染之间存在相关性,其中以CMV感染关系最为密切,可能作为其发病机制中的一个促发因素,最终引起胆道闭锁;抗病毒治疗可能会改善CMV感染EHBA预后。
Objective To study the relationship between viral infection and pediatric biliary atresia using tissue microarray. Methods The cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infection in the liver tissues of 42 patients with biliary atresia and 5 controls were detected by tissue microarray. Results Of the 42 patients with biliary atresia, 26 were CMV positive (61.9%), 3 were EBV positive (7.14%), and 5 were not detected in the control group. Conclusions There is a correlation between biliary atresia and viral infection, of which CMV infection is the most closely related, which may be a proinflammatory factor in its pathogenesis and finally cause biliary atresia. Antiviral therapy may improve the prognosis of EHBA infected with CMV.