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随着肿瘤基因研究,广泛运用自杀基因(suicidegene)用于各种恶性肿瘤治疗,CD(cytosine deaminase)、TK(thymidine kinase)等自杀基因治疗人类多种恶性肿瘤已取得了令人瞩目的成绩[1~3]。其中来自大肠杆菌的尿嘧啶磷酸核糖转移酶(uracil phosphoribosyltrans-ferase gene,UPRT)可
With the study of tumor genes, suicide gene has been extensively used in the treatment of various malignancies. Suicide genes such as cytosine deaminase (CD) and thymidine kinase (TK) have made remarkable achievements in many human malignancies [ 1 ~ 3]. Among them, uracil phosphoribosyltransferase gene (UPRT) from Escherichia coli