从雌激素的结构和功能、雌激素受体与骨代谢、人工破坏雌激素受体基因小鼠模型的建立、雌激素受体基因突变的男性病例分析、雌激素受体的同工型及雌激素受体基因多态性等 6个部分综述雌激素及其受体基因在骨质疏松发病中的作用及意义 ,旨在阐明骨质疏松症 ,尤绝经后骨质疏松症的发病及分子机制 ,为基础和临床研究提供系统的思路。 From the estrogen’s structure and function, estrogen receptor and bone metabolism, the establishment of mouse model of artificial destroying estrogen receptor gene, male case analysis of estrogen receptor gene mutation, estrogen receptor isoforms and estrogen receptor Hormone receptor gene polymorphism and other six parts review estrogen and its receptor gene in the pathogenesis of osteoporosis and its significance in order to elucidate the pathogenesis of osteoporosis, especially postmenopausal osteoporosis and molecular mechanisms , Provide systematic ideas for basic and clinical research.