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目的:研究细胞因子对正常人和胃癌伴慢性病性贫血(anemia of chronic cliseasis,ACD)的影响。方法:采用ELISA方法测定CD35和CD58水平,红细胞酵母花环法测定RBC-C3bRR和RBC-ICR,聚乙醇沉淀比浊法测定CIC,流式细胞术测定CD2。结果:胃癌组和正常对照组进行比较:RBC-C3b差异有统计学意义,P<0·01;RBC-ICR差异有统计学意义,P<0·05;CD35差异有统计学意义,P<0·01;而CD58虽然低于正常对照组,但差异无统计学意义,P>0·05;CIC测定结果均正常。结论:胃癌患者RBC-C3b、CD35和CD58水平下降与胃癌患者具有免疫活性的细胞因子有直接关系。但CD58无统计学意义。
Objective: To study the effects of cytokines on normal and gastric cancer with anemia of chronic cliseasis (ACD). Methods: The levels of CD35 and CD58 were measured by ELISA. The RBC-C3bRR and RBC-ICR were determined by the rosette method of erythrocytes, the CIC by polyacrylamide gel sedimentation turbidimetry and the CD2 by flow cytometry. Results: There were significant differences in RBC-C3b between the gastric cancer group and the normal control group (P <0.01); the difference of RBC-ICR was statistically significant (P <0.05); the difference of CD35 was statistically significant (P < 0.01). Although CD58 was lower than the normal control group, the difference was not statistically significant (P> 0.05). The results of CIC were normal. Conclusion: The decline of RBC-C3b, CD35 and CD58 in patients with gastric cancer is directly related to the immunocompetent cytokines in patients with gastric cancer. However, CD58 was not statistically significant.