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目的 为了解Ph染色体阳性 (Ph+ )成人急性B淋巴细胞白血病 (B -ALL)的免疫表型特征。方法 对 78例初治成人B -ALL形态学 (M)免疫学 (I)细胞遗传学 (C)分型结果进行分析。结果 Ph+ 的B -ALL占 2 5例(32 1 % ) ,其中伴髓系抗原 (CD1 3或CD33)表达 (My+ )有 1 4例 (56 0 % ) ,CD1 0和CD1 9均高表达 ,伴淋系抗原 (CD2或CD3或CD7)表达 (Ly+ )有 3例 (1 2 0 % ) ,CD34阳性 1 7例 (68 0 % )。对于Ph染色体阴性 (Ph- )的病例 ,My+ 有 1 2例 ,占 2 2 6 % ,而Ly+ 和CD34阳性的病例分别占 3 8%和 83 0 %。经分析发现 ,Ly+ 和CD34在Ph+ 和Ph+ 的病例中的阳性率差异无显著性。而Ph+ 的成人B -ALL伴My+ 高于Ph- 的成人B -ALL ,且差异具有显著性。结论 成人Ph+ B-ALL通常伴My+ 、CD34表达。Ph+ 与My+ 之间可能具有一定的联系 ,影响成人B -ALL的预后
Objective To understand the immunophenotypic characteristics of Ph chromosome-positive (Ph+) adult acute B-lymphocytic leukemia (B-ALL). Methods 78 cases of untreated adults with B-ALL morphology (M) immunology (I) cytogenetic (C) genotyping results were analyzed. Results Ph-B-ALL accounted for 25 cases (321%), of which 14 cases (56.0%) had myeloid antigen (CD1 3 or CD33) expression (My+), and CD1 0 and CD19 were highly expressed. There were 3 cases (12%) of lymphonoid antigen (CD2 or CD3 or CD7) expression (Ly+) and CD34 positive (170% (680%)). For Ph-negative (Ph-) cases, there were 12 cases of My+, accounting for 22.6%, while Ly+ and CD34-positive cases accounted for 38% and 83%, respectively. The analysis found that the positive rates of Ly+ and CD34 in Ph+ and Ph+ were not significantly different. While Ph+ adult B-ALL with My+ was higher than Ph- adult B-ALL, and the difference was significant. Conclusion Adult Ph+ B-ALL is usually associated with My+ and CD34 expression. There may be some relationship between Ph+ and My+, affecting the prognosis of adult B-ALL