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目的探讨复方丹参注射液辅助治疗重度子痫前期的疗效及对产后出血的影响。方法收集2012年4月-2016年2月间该院收治的重度子痫前期孕妇56例为研究对象,并将入组孕妇分为给予常规治疗作为对照组30例,在对照组治疗基础上,给予复方丹参注射液治疗作为观察组26例。治疗前、治疗7 d后,记录两组患者的血压、肾功能等疗效指标,采用凝血分析仪测定凝血功能指标;记录术后出血性事件发生情况。结果治疗前,两组血压、肾功能及凝血功能指标水平差异无统计学意义(P>0.05)。治疗7 d后,观察组平均收缩压(SBP)、平均舒张压(DBP)、尿蛋白(PRO)水平低于对照组,24 h尿量(24 h UV)水平高于对照组,血浆凝血功能指标纤维蛋白原(Fib)、D-二聚体(D-D)水平低于对照组,凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)水平高于对照组,肝肾功能指标丙氨酸转氨酶(ALT)、谷草转氨酶(AST)、血尿素氮(BUN)、血肌酐(Scr)含量低于对照组,差异有统计学意义(均P<0.05);观察组弥散性血管内凝血(DIC)、产后出血、失血性休克等出血事件发生率均低于对照组,差异有统计学意义(均P<0.05)。结论复方丹参注射液辅助治疗可优化重度子痫前期孕妇血压及肝肾功能,降低机体高凝状态,最终减少产后出血性事件发生率。
Objective To investigate the effect of compound Danshen injection in the treatment of severe preeclampsia and postpartum hemorrhage. Methods Fifty-six pregnant women with severe preeclampsia who were admitted to our hospital from April 2012 to February 2016 were enrolled in this study. The pregnant women were divided into treatment group (n = 30) and control group (n = 30). On the basis of the control group, Given compound Danshen injection as observation group of 26 cases. Before treatment, after 7 days of treatment, the curative indexes such as blood pressure and renal function of the two groups were recorded. The coagulation analyzer was used to measure the coagulation function index. The postoperative hemorrhagic events were recorded. Results Before treatment, there was no significant difference in blood pressure, renal function and coagulation function between the two groups (P> 0.05). After 7 days of treatment, the mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and urinary protein (PRO) in the observation group were lower than those in the control group, and the 24 h urine (24 h UV) The levels of fibrinogen (Fib), D-dimer (DD) were lower in the control group than those in the control group. The prothrombin time (PT) and activated partial thromboplastin time (APTT) ALT, AST, BUN and Scr were significantly lower than those in the control group (all P <0.05). In the observation group, diffuse intravascular coagulation (DIC), postpartum hemorrhage, hemorrhagic shock and other bleeding events were lower than the control group, the difference was statistically significant (P <0.05). Conclusions The adjuvant treatment with compound Danshen injection can optimize the blood pressure, liver and kidney function, reduce the hypercoagulability in pregnant women with severe preeclampsia, and ultimately reduce the incidence of postpartum hemorrhagic events.