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目的 :探讨初发慢性粒细胞白血病的临床特点、诊断和治疗。方法 :回顾性分析 1995～ 2 0 0 0年收治血液科住院的 5 5例初发患者。结果 :5 5例患者以脾肿大、白细胞增多、外周血及骨髓中出现多量中性中幼、晚幼粒及杆状核粒细胞为特征 ,88 1%患者Ph染色体阳性 ,15例 (占 2 7 3% )有明显出血表现。结论 :慢性粒细胞白血病是血液科的常见疾病 ,少数患者临床表现或骨髓涂片检查可不典型 ,治疗首选羟基脲。
Objective: To investigate the clinical features, diagnosis and treatment of primary chronic myeloid leukemia. Methods: A retrospective analysis of 55 cases of newly diagnosed patients hospitalized for hematology from 1995 to 2000 was conducted. Results: Fifty-five patients were characterized by splenomegaly, leukocytosis, a large number of neutrophil, late promyelocytic and rod-like granulocytes in peripheral blood and bone marrow. Ph chromosome was found in 88% of the patients, 15 273%) had significant bleeding. CONCLUSION: Chronic myeloid leukemia is a common disease of hematology. The clinical manifestations or bone marrow smear tests of a few patients may not be typical, and the first choice is hydroxyurea.