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目的分析并探讨厄贝沙坦与氢氯噻嗪的联合疗法在老年原发性高血压病的临床治疗中的应用效果。方法选取2011年1月-2013年1月医院收治的原发性高血压患者120例,随机分为观察组和对照组各60例。对照组给予厄贝沙坦治疗,观察组在对照组基础上加用氢氯噻嗪实施临床治疗。观察比较2组患者的治疗效果、不良反应发生率以及治疗前后血糖(GLU)、血总胆固醇(TC)、三酰甘油(TG)等指标的变化情况。结果治疗前,2组患者的GLU、TC、TG等指标比较差异无统计学意义(P>0.05)。治疗后,2组GLU、TC、TG等指标与治疗前无明显改变;治疗总有效率明显高于对照组患者,不良反应发生率明显低于对照组,差异均具有统计学意义(P<0.05)。结论在应用厄贝沙坦对老年原发性高血压患者进行治疗时加用氢氯噻嗪,能够显著地提高治疗有效率,优化患者的各项指标情况,且安全性强,值得在临床中推广使用。
Objective To analyze and discuss the effect of combination therapy of irbesartan and hydrochlorothiazide in the clinical treatment of senile essential hypertension. Methods 120 patients with essential hypertension treated in our hospital from January 2011 to January 2013 were randomly divided into observation group (60 cases) and control group (60 cases). The control group was treated with irbesartan. The observation group was treated with hydrochlorothiazide on the basis of the control group. The therapeutic effects, the incidence of adverse reactions and the changes of GLU, TG and triglyceride before and after treatment were observed and compared between the two groups. Results Before treatment, there was no significant difference in GLU, TC, TG among the two groups (P> 0.05). After treatment, the indexes of GLU, TC and TG in the two groups had no significant change with those before treatment; the total effective rate was significantly higher than that of the control group, the incidence of adverse reactions was significantly lower than that of the control group (P <0.05 ). Conclusion The application of irbesartan in the treatment of senile essential hypertension in patients with hydrochlorothiazide, can significantly improve the treatment efficiency, optimize the patient’s indicators, and safety, it is worth to promote the use of the clinic.