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乙型肝炎表面抗原(HB sAg)的携带状态是世界性问题。有些国家的发生率占全人口的10％以上。本文对180名反复阳性一年以上的HB_sAg携带者作随访研究,希能阐明:1)携带状态的期限;2)临床过程特别是发展成慢性肝病、肝细胞癌或肝外病情;3)肝功能试验的变化型式及其意义;4)肝活检所见及其系列变化。 180名携带者经随访1～8年,平均4年。男女比率为3.2:1。全部病人都做肝功能试验、HB_sAg、抗一HB_s、HB_eAg和抗HB_e;30例肝功能正常无症状携带者均检测IgM抗-HB_c;36例作肝活检,其中15例系列活检达6次,36例总共作73次活检。再将病人按组织学改变分为二组:(1)病理改变主要在门脉区和(2)主
The carrier status of hepatitis B surface antigen (HBsAg) is a worldwide problem. Some countries account for more than 10% of the population. In this study, 180 repeat HBsAg carriers who were positive for more than one year were followed up, and hopefully elucidated: 1) the duration of the carrier status; 2) the clinical course of progression to chronic liver disease, hepatocellular carcinoma or extrahepatic disease; 3) Functional tests of the changing patterns and their significance; 4) Liver biopsy seen and its series of changes. 180 carriers were followed up for 1 to 8 years, an average of 4 years. The ratio of men to women is 3.2: 1. All patients had liver function tests, HBsAg, anti-HB_s, HB_eAg and anti-HB_e; IgM anti-HBc was detected in 30 normal asymptomatic carriers; 36 were biopsied for liver biopsy, of which 15 were biopsy up to 6 times, 36 cases for a total of 73 biopsies. Then the patients were divided into two groups according to histological changes: (1) pathological changes mainly in the portal area and (2) the main