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目的 观察精子数目异常与小Y染色体及内分泌性腺激素水平。方法 对262名少精及无精症患者检测染色体,并对其中11例小Y染色体患者及随机抽取的15例Y染色体正常的患者运用磁性分离酶免疫测定法分别检测性腺激素。 结果 小Y染色体检出率为4.19%(11/262),其内分泌性腺激素均呈高卵泡刺激素、高黄体生成素和低睾酮水平,与Y染色体正常的无精及少精症患者相比较,差异有显著性(P<0.05)。而小Y染色体不同精子数组各内分泌性腺激素比较,差异无显著性(P>0.05)。结论 精子数目异常可能与小Y染色体有关,小Y染色体基因改变可能是导致其内分泌性腺激素的变化因素。
Objective To observe the number of sperm abnormalities and small Y chromosome and endocrine ghrelin levels. Methods Chromosomes were detected in 262 patients with oligozoospermia and oligospermia, and 11 cases with small Y chromosome and 15 cases with normal Y chromosome were detected by magnetic separation enzyme immunoassay to detect gonadal hormone respectively. Results The detection rate of small Y chromosome was 4.19% (11/262). The endocrine gland hormones showed high follicle stimulating hormone, high luteinizing hormone and low testosterone, compared with those with normal Y chromosome and azoospermia , The difference was significant (P <0.05). There was no significant difference in endocrine gland hormones among small Y chromosomes with different sperm count (P> 0.05). Conclusion The abnormal number of sperm may be related to the small Y chromosome. The change of small Y chromosome may be the factor that leads to the change of its endocrine gonadal hormone.