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目的探寻早期糖尿病肾病(DN)的有效防治措施。方法将2003年7月至2006年7月在湖北省阳新县人民医院内科就诊的42例早期 DN 患者分为治疗组与对照组,治疗组注射胰岛素和口服辛伐他汀,对照组口服降糖药。观察两组疗效。结果治疗组空腹血糖(FBG)、餐后2 h 血糖(2hPPBG)控制良好,对照组控制不理想(P<0.01)。治疗组治疗6周的血清总胆固醇(TC)、血清三酰甘油(TG)、血清低密度脂蛋白胆固醇(LDL-C)明显下降(P<0.01);治疗12周后的血清高密度脂蛋白胆固醇(HDL-C)明显升高(P<0.01);对照组上述指标改变无显著性意义。24 h 尿白蛋白排泄率(UAE)在对照组治疗期间无明显变化,而治疗组在治疗6周后开始下降(P<0.05)。结论胰岛素与辛伐他汀合用可有效治疗早期 DN。
Objective To explore the effective prevention and treatment of early diabetic nephropathy (DN). Methods From July 2003 to July 2006, 42 cases of early stage DN patients treated in Yangxin County People’s Hospital of Hubei Province were divided into treatment group and control group. The treatment group received insulin and oral simvastatin, while the control group received oral hypoglycemic agents . The two groups were observed. Results The fasting blood glucose (FBG) and postprandial 2h blood glucose (2hPPBG) were well controlled in the treatment group, but not in the control group (P <0.01). Serum total cholesterol (TC), serum triglyceride (TG) and serum low density lipoprotein cholesterol (LDL-C) were significantly decreased in the treatment group after 6 weeks of treatment (P <0.01); serum high density lipoprotein Cholesterol (HDL-C) was significantly increased (P <0.01); the control group no significant change in the above indicators. 24 h urinary albumin excretion rate (UAE) did not change significantly in the control group during treatment, while the treatment group began to decline after 6 weeks of treatment (P <0.05). Conclusion The combination of insulin and simvastatin can effectively treat early DN.