论文部分内容阅读
目的:探讨地屈孕酮在先兆流产治疗中的临床作用。方法:776例先兆流产孕妇采用随机数表法分为两组,每组388例。所有孕妇均卧床充分休息,加强营养。对照组患者予口服黄体酮胶囊100 mg,po,bid,连续服用7 d。观察组患者给予地屈孕酮口服,首剂40 mg,后每12 h 10 mg,连续服用7 d。比较治疗前后两组患者的血清孕酮值、临床症状缓解时间、观察两组临床疗效及不良反应发生情况。结果:治疗后,观察组孕妇血清孕酮值显著高于对照组,临床症状缓解时间显著短于对照组(P<0.05)。对照组保胎成功率82.98%,低于观察组的保胎成功93.81%(P<0.05)。对照组不良反应发生率为6.19%,治疗组不良反应发生率为3.61%,两组差异无统计学意义(P>0.05)。结论:应用地屈孕酮治疗先兆流产的效果显著,其可有效提高患者的血清孕酮值,改善孕妇临床症状,且不良反应轻微,值得在临床上推广使用。
Objective: To investigate the clinical effect of dydrogesterone in the treatment of threatened abortion. Methods: 776 cases of threatened abortion pregnant women using random number table divided into two groups, each group 388 cases. All pregnant women are fully rest in bed, strengthen nutrition. Patients in the control group were given oral progesterone capsules 100 mg, po, bid for 7 consecutive days. Patients in the observation group were given dexyprogesterone orally, the first dose of 40 mg, every 12 h after 10 mg, taking 7 consecutive days. The serum progesterone value, clinical symptom relief time before and after treatment were compared between two groups to observe the clinical efficacy and adverse reactions. Results: After treatment, the serum progesterone level in pregnant women in observation group was significantly higher than that in control group, and the time to relieve clinical symptoms was significantly shorter than that in control group (P <0.05). In the control group, the success rate of miscarriage was 82.98%, which was lower than that of the observation group (93.81%, P0.05). The incidence of adverse reactions in the control group was 6.19%, and the incidence of adverse reactions in the treatment group was 3.61%. There was no significant difference between the two groups (P> 0.05). Conclusion: The application of dydrogesterone in the treatment of threatened abortion is significant. It can effectively raise the serum progesterone value of the patients and improve the clinical symptoms of pregnant women with mild adverse reactions. It is worth popularizing in clinic.