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目的 探讨急性脑血管病患者血清神经元特异性烯醇化酶 (NSE)浓度的变化及其临床意义。方法 应用酶联免疫分析法测定 5 0例急性脑血管病患者和 2 0例正常人血清NSE浓度。病例组包括脑出血2 0例、脑梗死 2 0例、蛛网膜下腔出血 10例。应用直线相关分析方法分析NSE浓度与病灶大小、病情严重程度以及预后的关系。结果 对照组的NSE浓度为 6 .14± 4 .39μg/L。脑出血组NSE浓度为36 .30± 2 4 .5 9μg/L ;脑梗死组NSE浓度为34.95± 2 2 .88μg/L ;蛛网膜下腔出血组NSE浓度为33.4 8± 10 .79μg/L。病例组与对照组之间存在明显的统计学差异 (P <0 .0 1) ,患者组之间无明显统计学差异 (P >0 .0 5 )。NSE浓度与病变的大小、病情严重程度 (GCS评分 )和预后 (GOS评分 )之间存在相关性 (P <0 .0 1)。结论 急性脑血管病患者血清NSE浓度明显增高 ,NSE浓度的高低不仅为神经元损伤程度提供定量信息 ,而且也是判断病情、评估预后的重要参数。
Objective To investigate the changes of serum neuron specific enolase (NSE) in patients with acute cerebrovascular disease and its clinical significance. Methods Serum NSE levels in 50 patients with acute cerebrovascular disease and 20 normal individuals were determined by enzyme-linked immunosorbent assay. The cases included 20 cases of cerebral hemorrhage, 20 cases of cerebral infarction and 10 cases of subarachnoid hemorrhage. Linear correlation analysis was used to analyze the relationship between the concentration of NSE and the size of the lesion, the severity of the disease and the prognosis. Results The NSE concentration in the control group was 6 .14 ± 4 .39 μg / L. The concentration of NSE in cerebral hemorrhage group was 36 .30 ± 24.59μg / L; the concentration of NSE in cerebral infarction group was 34.95 ± 22.88μg / L; the concentration of NSE in subarachnoid hemorrhage group was 33.48 ± 10.79μg / L . There was a significant difference between the case group and the control group (P <0.01). There was no significant difference between the two groups (P> 0.05). There was a correlation between the NSE concentration and the size of the lesion, the severity of the disease (GCS score) and the prognosis (GOS score) (P <0.01). Conclusion Serum NSE levels are significantly increased in patients with acute cerebrovascular disease. NSE concentration not only provides quantitative information for the degree of neuronal injury, but also is an important parameter for judging the disease and assessing the prognosis.