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目的探讨血小板相关抗体(PAIg)检测在血小板减少症中的临床意义。方法选择110例血小板减少症患者及10例外周血系均在正常范围的健康体检者(正常对照组),采用ELSIA法进行PAIgG、PAIgA、PAIgM3项联合检测。结果特发性血小板减少性紫癜(ITP)、再生障碍性贫血(AA)、骨髓增生异常综合征(MDS)、血液系统肿瘤、肝病患者PAIg阳性率均明显高于正常对照组。ITP、AA、血液肿瘤组及肝病组患者的PAIgG、PAIgA、PAIgM值均高于正常对照组,差异有统计学意义(P<0.05)。结论PAIg的检测有助于了解血小板减少症的发生机制。
Objective To investigate the clinical significance of platelet-associated antibody (PAIg) detection in thrombocytopenia. Methods One hundred and thirteen patients with thrombocytopenia and 10 healthy controls were enrolled in this study. Normal controls were included in the study. ELSIA was used to detect PAIgG, PAIgA and PAIgM3. Results The positive rate of PAIg in idiopathic thrombocytopenic purpura (ITP), aplastic anemia (AA), myelodysplastic syndrome (MDS), hematologic malignancies and liver disease were significantly higher than those in normal controls. PAIgG, PAIgA and PAIgM in patients with ITP, AA, hematological tumor and liver disease were significantly higher than those in normal control group (P <0.05). Conclusion The detection of PAIg helps to understand the mechanism of thrombocytopenia.