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618环氧树脂灌浆液(JX—1)为国内新研制成的一种化学灌浆液,广泛应用于建筑工程中。本文报道JX—1的急性毒性、蓄积性以及JX—1和主剂618环氧树脂(E—51)的潜在致癌性、诱突变性的研究结果。JX—l可经胃肠道吸收,经皮吸收缓慢,对皮肤、粘膜有轻度刺激作用。经口LD_(50)大鼠为3540.53mg/kg,属低毒类化合物。蓄积系数>5,属弱蓄积毒性。JX—1和E—51对大鼠骨髓细胞染色体畸变试验阴性,但Ames试验和小鼠骨髓细胞SCE试验均为阳性。
618 epoxy grouting fluid (JX-1) is a newly developed chemical grouting fluid that is widely used in construction projects. In this paper, we report the acute toxicity and accumulation of JX-1 as well as the potential carcinogenicity and mutagenicity of JX-1 and main agent 618 epoxy resin (E-51). JX-l can be absorbed through the gastrointestinal tract, percutaneous absorption is slow, mild irritation of the skin, mucous membrane. Oral LD_ (50) rats 3540.53mg / kg, is a low-toxic compounds. Accumulation coefficient> 5, is a weak accumulation of toxicity. JX-1 and E-51 were negative for rat bone marrow cell chromosome aberration, but Ames test and mouse bone marrow SCE test were positive.