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慢性乙型肝炎病毒(HBV)感染是全球性公共卫生问题,慢性HBV感染可导致不同类型的肝病,包括慢性肝炎、肝硬化和肝细胞癌。大量的研究表明,HBV基因组易发生变异,形成不同的基因型,HBV基因型具有明显的地理分布和种族分布特点,它与疾病进展和临床转归有关,不同的基因型对抗病毒治疗的应答也不完全相同,近年来国内外学者从流行病学、分子生物学、临床医学开展了大量的研究,本文就国内外乙型肝炎病毒基因型及其临床意义的研究进展进行了综述。
Chronic hepatitis B virus (HBV) infection is a global public health problem, chronic HBV infection can lead to different types of liver disease, including chronic hepatitis, cirrhosis and hepatocellular carcinoma. A large number of studies have shown that the HBV genome prone to mutation, the formation of different genotypes, HBV genotypes have obvious geographical distribution and ethnic distribution, which is related to disease progression and clinical outcome, different genotypes response to antiviral therapy Not exactly the same, in recent years, domestic and foreign scholars from epidemiology, molecular biology, clinical medicine carried out a large number of studies, this article on the hepatitis B virus genotypes at home and abroad and its clinical significance of the research are reviewed.