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本文报告2例异搏定、卡马西平合用而致卡马西平神经毒性反应.停用异搏定后,神经毒性反应消失.例1,女,55岁,患癫痫已40年,多年来临睡前服用苯巴比妥130mg.从1986年8月起加用卡马西平200mg、4次/日.癫痫发作每月通常2次.1987年2月11日用药后测定血清卡马西平浓度为8.2μg/ml(正常4～12μg/ml),苯巴比妥19μg/ml(正常10～35μg),此期间因血压不稳定用硝苯吡啶和可乐定控制血压.此后停用以上二药,而开始用异搏定80mg,4次/日,双氢克尿塞12.5mg,1次/
In this paper, we report 2 cases of verapamil, carbamazepine combined with carbamazepine neurotoxicity caused by the withdrawal of verapamil after the disappearance of neurotoxic reactions.Example 1, female, 55 years old, suffering from epilepsy for 40 years, many years of sleep Before taking phenobarbital 130mg. From August 1986 plus carbamazepine 200mg, 4 times / day. Epileptic seizures usually 2 times a month on February 11, 1987 measured serum carbamazepine concentration of 8.2 (normal 4 ~ 12μg / ml), phenobarbital 19μg / ml (normal 10 ~ 35μg) during this period due to unstable blood pressure with nifedipine and clonidine to control blood pressure.After then stop the above two drugs, and Start with verapamil 80mg, 4 times / day, hydrochlorothiazide 12.5mg, 1 /