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目的了解白血病抑制因子(LIF)在子宫肌瘤组织和正常子宫肌组织中的表达是否存在差异,探讨LIF与子宫肌瘤发病的相关性。方法运用免疫组织化学技术检测30例子宫肌瘤病人子宫肌瘤组织(实验组)和正常子宫肌组织(对照组)中LIF的表达。结果 LIF在所有标本中均有低表达,但在实验组和对照组无明显差异(P>0.05)。结论 LIF与子宫肌瘤的发病可能无明显关系,但可能对维持子宫肌组织的正常分化、使子宫肌瘤组织不发生恶变具有一定的作用。
Objective To investigate the expression of leukemia inhibitory factor (LIF) in uterine fibroid tissue and normal uterine myometrium, and to investigate the correlation between LIF and the incidence of uterine fibroids. Methods The expression of LIF in uterine fibroid tissue (experimental group) and normal uterine muscle tissue (control group) of 30 patients with uterine myoma was detected by immunohistochemistry. Results LIF expression was low in all samples, but there was no significant difference between experimental group and control group (P> 0.05). Conclusion LIF may not be related to the pathogenesis of uterine fibroids, but may play a role in maintaining the normal differentiation of uterine muscle tissue and preventing malignant transformation of uterine fibroids.