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目的探讨乙型肝炎肝硬化患者血清HBV-DNA含量与肝脏剪切波弹性成像(SWE)杨氏模量值的相关性。方法检测109例乙型肝炎肝硬化患者血清HBV-DNA,同时应用SWE对其进行肝脏弹性模量值的检测,将两者结果进行分析。依患者血清的HBV-DNA含量将患者分为三组,低效价组、中效价组、高效价组。结果三组患者杨氏模量值均显著增加,且血清HBV-DNA含量与肝脏杨氏模量值之间呈正相关(P<0.001)。患者血清HBV-DNA不同含量三组间差异有统计学意义(P<0.001),组内差异性分析表明,低效价组与中、高效价组间比较分别具有差异性,中、高效价组间比较无统计学差异,分析低、高效价组间的ROC曲线结果,得出曲线下面积为0.802,灵敏度为76.0%、特异度为67.9%。结论乙型肝炎肝硬化时,剪切波弹性成像杨氏模量值随血清HBV-DNA含量增加而增加,高效价HBV-DNA的诊断临界值为13.30kPa。
Objective To investigate the relationship between serum HBV-DNA level and Young’s modulus of liver in shear-wave elastography (SWE) in patients with hepatitis B cirrhosis. Methods Serum HBV-DNA was detected in 109 patients with hepatitis B cirrhosis. SWE was used to detect the elastic modulus of the liver, and the results were analyzed. The patients were divided into three groups according to the HBV-DNA content of the patient’s sera: low titer group, middle titer group and high titer group. Results The Young’s modulus of all three groups were significantly increased, and the serum HBV-DNA content was positively correlated with the Young’s modulus (P <0.001). There were significant differences among the three groups (P <0.001), and there were significant differences among the three groups in the serum HBV-DNA levels (P <0.001). The intra-group difference analysis showed that there were significant differences between low- The results showed that the area under the curve was 0.802, the sensitivity was 76.0% and the specificity was 67.9%. Conclusions The Young’s modulus of shear wave elastography increases with the increase of serum HBV-DNA during the cirrhosis of hepatitis B. The critical value of high-titer HBV-DNA diagnosis is 13.30kPa.