血浆皮质类固醇浓度产生对地塞米松抑制作用的抵抗现象,引起了精神病学研究的很大兴趣。当前已查明造成地塞米松抑制试验(DST)失败的原因有多种,有医疗和技术上的因素,包括多种药物的同时服用(苯妥英、巴比妥酸盐类、眠尔通、苯乙哌啶酮、甲普里隆、安眠酮、雌激素类和卡巴咪嗪)、在DST前戒断长期使用的苯二氮(艹卓)类或抗胆硷能的抗抑郁剂治疗、重症和轻症内科疾病、酒精戒断和妊娠等。体重下降也是造成DST假阳性的一种干扰因素,但对其重要性存有 Plasma corticosteroid concentrations produce resistance to dexamethasone, which is of great interest in psychiatric research. There are a variety of reasons that have led to the failure of the dexamethasone suppression test (DST) currently identified, including medical and technical factors including simultaneous use of multiple medications (phenytoin, barbiturates, Etanercept, methylepirone, methaqualone, estrogens and carbamazepine), benzodiazepines or anticholinergic antidepressants used for long-term withdrawal from DST, And mild medical conditions, alcohol withdrawal and pregnancy. Weight loss is also a distraction to DST false positives, but their importance exists