细胞核因子κB(NF κB)家族及其介导的细胞信号转导通路广泛调控着人类免疫和炎症反应中一系列基因的表达 ,同时也发现它对肿瘤的发生发展有着重要作用 ,特别是它可以调控一些细胞凋亡相关基因如TRAF家族、IAPs家族、Bcl 2家族及FLIP基因、p5 3基因、COX 2基因的转录表达 ,从而大大提高肿瘤细胞的抗凋亡能力。本文就近年来对NF κB通路与肿瘤抗凋亡关系的研究进展作一综述 The nuclear factor κB (NF κB) family and its signal transduction pathway widely regulate the expression of a series of genes in human immune and inflammatory response, and also find it plays an important role in tumorigenesis and development. In particular, it can It regulates the transcriptional expression of some apoptosis-related genes such as TRAF family, IAPs family, Bcl 2 family and FLIP gene, p5 3 gene and COX 2 gene, thereby greatly improving the anti-apoptotic ability of tumor cells. This review summarizes recent progress in the study of the relationship between NF-κB pathway and tumor anti-apoptosis