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目的:探讨健脾补肾化瘀方对肺癌的抑制和化疗的协同增效作用。方法:选择小鼠移植性Lewis肺癌为模型,分别观察健脾补肾化瘀方以及与顺铂(DDP)联合应用时的抑瘤率。结果:健脾补肾化瘀方对小鼠移植性Lewis肺癌有显著的抑制作用(P<0.01),并能显著增强DDP对小鼠Lewis肺癌的抑瘤作用(P<0.05)。结论:表明健脾补肾化瘀方对动物移植性肺癌有抑制和对化疗药物的协同增效作用。
Objective: To investigate the effect of invigorating the spleen and invigorating the kidney and removing blood stasis on the inhibition of lung cancer and the synergistic effect of chemotherapy. Methods: Mouse Lewis lung carcinoma (MDP) was selected as a model to observe the inhibitory effect of Jianpi Bushen Huayu Recipe and its combination with cisplatin (DDP). Results: Jianpi Bushen Huayu Recipe had significant inhibitory effect on transplanted Lewis lung carcinoma in mice (P <0.01), and significantly enhanced the inhibitory effect of DDP on Lewis lung carcinoma in mice (P <0.05). Conclusion: It is indicated that Jianpi Bushen Huayu Recipe has inhibitory effect on animal transplant lung cancer and synergism on chemotherapeutic drugs.