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[目的]在完成戊二醛毒性检验第1阶段相关实验的基础上,开展第2阶段毒性试验的亚慢性毒性试验,初步探讨戊二醛“最大未观察到有害作用剂量”值范围。[方法]参考GB 15193.13-2003进行高、中、低剂量经口90 d喂养实验。[结果]高、中、低3个剂量组动物在生长发育、体重增长趋势、脏器系数和食物利用率与空白对照组动物无明显差异。高、中剂量组在红细胞、血红蛋白、白细胞高于空白对照组,差异有显著意义(P<0.05)或极显著意义(P<0.01),且存在低、中、高3个剂量组的剂量-效应关系。[结论]戊二醛“最大未观察到有害作用剂量”值初步估计在低剂量组(0.438mg/kg体重)与中剂量组(4.38mg/kg体重)之间;血常规指标检测或可作为发现戊二醛职业接触工人慢性中毒的早期指标。
[Objective] The purpose of this study was to carry out the sub-chronic toxicity test of stage 2 toxicity test on the basis of the related experiments of stage 1 of the glutaraldehyde toxicity test and to discuss the glutaraldehyde value range of “the maximum unnoticeable dose of harmful side effect”. [Method] Refer to GB 15193.13-2003 for high, medium and low dose oral 90 d feeding experiments. [Result] There was no significant difference in the growth, weight gain, organ coefficient and food utilization among the three high, middle and low dose groups compared with the blank control group. There was significant difference (P <0.05) between the high and middle dose groups of erythrocyte, hemoglobin and leukocyte in the blank control group (P <0.01) Effect relationship. [Conclusion] The preliminary evaluation of glutaraldehyde “the maximum unnoticeable dose” value was preliminarily estimated between the low dose group (0.438mg / kg body weight) and middle dose group (4.38mg / kg body weight) May be used as an early indicator of chronic exposure to glutaraldehyde exposure workers.