论文部分内容阅读
目的观察拉坦前列素用于外滤过或虹膜周切术后的残余性闭角型青光眼的降眼压效果。方法采用随机、单盲、平行对照试验,选取外滤过或虹膜周切术后的残余性闭角型青光眼患者(眼压≥21mmHg且≤35mmHg,前房角检查至少累计90度范围内看到部分睫状体带),拉坦前列素组每晚一次,噻吗心安对照组早、晚各用一次,共观察8周。分别记录用药前、用药后1周、2周、4周、8周9am以及用药前、用药后8周4pm的眼压值。结果拉坦前列素组入选25例(25只眼),噻吗心安组入选24例(24只眼),两组用药后眼压都明显下降,拉坦前列素组从用药前的(24.73±3.90)mmHg(1mmHg=0.133kPa)降至8周时的(16.08±3.86)mmHg,下降幅度为35.0%;噻吗心安组从(26.00±4.44)mmHg降至(17.53±3.97)mmHg,下降幅度为32.6%。不同时间点上午两组眼压没有显著差异,而用药后8周4pm拉坦前列素组的眼压(15.33±3.16)mmHg明显低于噻吗心安组(18.76±4.13)mmHg(t=-3.016,P<0.05)。结论拉坦前列素可有效降低外滤过或虹膜周切术后的残余性闭角型青光眼的眼压,其作用较噻吗心安更持久。
Objective To observe the hypotensive effect of latanoprost on residual angle-closure glaucoma after external filtration or iridectomy. Methods Randomized, single-blind, parallel-controlled trials were performed in patients with residual angle-closure glaucoma (IOP ≥ 21 mmHg and ≤ 35 mmHg) and anterior chamber angle examination of at least 90 degrees Part of the ciliary body zone), latanoprost group once a night, timolol control group early and late each use, observed a total of 8 weeks. The intraocular pressure (IOP) were recorded before treatment, 1 week, 2 weeks, 4 weeks, 8 weeks and 9 months after treatment and 4 weeks after treatment. Results Twenty-five patients (25 eyes) received latanoprost and 24 patients (24 eyes) received timolol. The intraocular pressure (IOP) of the two groups were significantly decreased after treatment (24.73 ± (26.08 ± 3.86) mmHg decreased from (26.00 ± 4.44) mmHg to (17.53 ± 3.97) mmHg at the 3rd week (3.90) mmHg (1mmHg = 0.133kPa) 32.6%. There was no significant difference in intraocular pressure between the two groups at different time points, while intraocular pressure (15.33 ± 3.16) mmHg in latanoprost group at 4 weeks after 8 weeks of treatment was significantly lower than that of timolol group (18.76 ± 4.13) mmHg (t = -3.016 , P <0.05). Conclusions Latanoprost can effectively reduce the intraocular pressure (IOP) of residual angle-closure glaucoma after perifiltration or peri-iris, which is more effective than timolol.