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编辑部:贵刊于1998年第19卷第2期第94～95页研究报告栏目中,刊登了胡亮钉医师等撰写的文章《白血病患者异基因骨髓移植后供者源白血病复发二例》,我们很感兴趣,如果有骨髓移植后供者细胞在患者体内恶变的确凿证据,对探讨白血病病因学,了解白血病是否由于造血环境影响导致细胞突变有重要意义。胡医师等用3个方面的证据表明患者复发的白血病是供者源的,包括从染色体水平分析核型变化,基因水平分析指纹图谱以及用免疫反应分析血型变化。对这些标准我
Editorial Office: In your research report in the 19th volume, 1998, Vol. 19, No. 2, pp. 94-95, an article entitled “Recurrence of donor-derived leukemia after allogeneic bone marrow transplantation in patients with leukemia” was published by Dr. Hu Liangnao. We are very interested, if there is conclusive evidence of malignant transformation of donor cells in patients after bone marrow transplantation, to explore the etiology of leukemia, to understand whether leukemia due to hematopoietic environmental effects leading to cell mutation is of great significance. Dr. Hu and colleagues used 3 areas of evidence to show that patients with relapsed leukemia were donor-sourced, including analysis of karyotypic changes from the chromosome level, fingerprint analysis of gene level analysis, and analysis of blood group changes using immune responses. To these standards I