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目的探讨甲状腺功能异常患者血清TSH和甲状腺激素水平的变化及临床意义。方法采用微粒子化学发光免疫分析法,检测了637例甲状腺功能异常患者和102例健康对照组血清中的TT3、TT4、TSH、FT3、FT4含量。结果患者组检出甲亢患者325例,甲减患者312例,甲亢患者TT3、TT4、FT3、FT4含量明显增高(分别为:3.58±0.85 nmol/L、168.64±35.62 nmol/L、8.26±2.58 pmol/L、21.36±5.64 pmol/L),TSH则明显下降(0.10±0.06 m IU/L)。而甲减患者血清TT3、TT4、FT4明显降低(分别为:1.26±0.49 nmol/L、60.82±29.91 nmol/L、5.58±2.18 pmol/L),TSH明显增高(38.25±30.32 m IU/L),与健康对照组比较均有显著异常(均P<0.001),甲减患者血清FT3含量降低不明显(P>0.05)。结论测定血清TSH和甲状腺激素水平有助于甲状腺功能异常患者的诊断及病情严重程度与预后的判断。
Objective To investigate the changes and clinical significance of serum TSH and thyroid hormone in patients with thyroid dysfunction. Methods The serum levels of TT3, TT4, TSH, FT3 and FT4 in 637 patients with thyroid dysfunction and 102 healthy controls were detected by chemiluminescence immunoassay. Results 325 patients with hyperthyroidism and 312 patients with hypothyroidism were detected in patients with hyperthyroidism. The levels of TT3, TT4, FT3 and FT4 were significantly increased in patients with hyperthyroidism (3.58 ± 0.85 nmol / L, 168.64 ± 35.62 nmol / L, 8.26 ± 2.58 pmol /L, 21.36 ± 5.64 pmol / L), TSH decreased significantly (0.10 ± 0.06 m IU / L). However, the serum levels of TT3, TT4 and FT4 in patients with hypothyroidism were significantly lower (1.26 ± 0.49 nmol / L, 60.82 ± 29.91 nmol / L and 5.58 ± 2.18 pmol / L respectively) and TSH was significantly higher (38.25 ± 30.32 m IU / L) (All P <0.001). The serum FT3 level in hypothyroidism patients was not significantly reduced (P> 0.05). Conclusion The determination of serum TSH and thyroid hormone levels is helpful for the diagnosis of patients with abnormal thyroid function and the judgment of severity and prognosis.