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[目的]探讨愈疡止痛(YYZT)煎剂对实验性大鼠十二指肠溃疡(DU)愈合质量的影响。[方法]用L-半胱胺酸盐酸盐复制大鼠DU模型,设立空白对照(A)组、病理模型(B)组、YYZT(C)组、雷尼替丁(D)组。3周后处死动物,观察溃疡愈合程度并评价溃疡愈合质量,测定胃液pH值及血清表皮生长因子(EGF)水平。[结果]C组胃酸较其余各组均降低(P<0.05);C组胃液pH值及血清EGF较其余各组明显升高(P<0.05,<0.01)。[结论]YYZT煎剂在提高溃疡愈合方面有明显优势,其作用机制可能与减少胃酸分泌、升高血清EGF有关。
[Objective] To investigate the effect of decoction of YYZT on the healing quality of duodenal ulcer (DU) in experimental rats. [Method] L-cysteine hydrochloride was used to replicate rat DU model and blank control (A) group, pathological model (B) group, YYZT (C) group and ranitidine (D) group were established. After 3 weeks, the animals were sacrificed to observe the degree of ulcer healing and evaluate the quality of ulcer healing. The gastric juice pH and serum epidermal growth factor (EGF) levels were measured. [Results] The gastric acid in group C was lower than that in other groups (P<0.05). The gastric juice pH value and serum EGF in group C were significantly higher than those in other groups (P<0.05, <0.01). [Conclusion] YYZT decoction has obvious advantages in improving ulcer healing, and its mechanism may be related to reducing gastric acid secretion and increasing serum EGF.