TAp63基因在多发性骨髓瘤中的表达及作用

来源 :皖南医学院学报 | 被引量 : 0次 | 上传用户:jayslacker
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目的:探讨TAp63 mRNA在多发性骨髓瘤( MM)中的表达及其在MM发病和预后中的可能作用。方法:采用RT-PCR检测19例MM患者骨髓及10例非恶性血液病患者骨髓中TAp63 mRNA的表达水平。结果:TAp63 mRNA在MM患者骨髓及非恶性血液病患者骨髓中平均灰度值分别为0.912±0.424、0.315±0.035,两者比较有显著性差异(P<0.001);其中ISS分期Ⅲ期患者的TAp63 mRNA平均灰度值显著高于Ⅰ期及Ⅱ期患者(P=0.000),同时MM患者TAp63
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