目的探讨运动疗法对急性脑梗死患者血中的脑源性神经营养因子(BDNF)的影响。方法选取2013年9月~2014年9月解放军第三〇三医院收治的急性脑梗死患者30例,以同意运动治疗的18例为运动组,以不同意运动治疗的12例为对照组。运动组给予良肢体位摆放和被动运动,并同时给予抗血小板聚集、改善循环、营养神经、扩张脑血管等治疗。对照组只给予抗血小板聚集、改善循环、营养神经、扩张脑血管等治疗。采用酶联免疫吸附法(ELISA)检测治疗前,治疗后1、2周血液中的BDNF水平。结果两组治疗后BDNF水平均高于治疗前,差异有统计学意义(P<0.05);运动组治疗后14 d BDNF水平[(101.03±3.34)pg/mg]高于治疗后7 d[(68.12±1.41)pg/mg],差异有统计学意义(P<0.05);运动组治疗后7、14 d BDNF水平均高于对照组[(66.17±1.32)、(77.15±2.29)pg/mg],差异有统计学意义(P<0.05)。对照组有效率(75.0%)明显低于运动组(88.9%),差异有高度统计学意义(P<0.01)。结论运动疗法可以促进DBNF的表达以及改善患者临床症状。 Objective To investigate the effect of exercise therapy on brain-derived neurotrophic factor (BDNF) in patients with acute cerebral infarction. Methods Thirty patients with acute cerebral infarction admitted to the 303 Hospital of PLA from September 2013 to September 2014 were selected as the exercise group and the 12 patients who did not agree to exercise therapy as the control group. Exercise group to give physical placement and passive limb movement, and at the same time give anti-platelet aggregation, improve circulation, nourishing nerves, dilated cerebrovascular and other treatment. The control group only given anti-platelet aggregation, improve circulation, nourishing nerves, dilated cerebrovascular and other treatment. The levels of BDNF in blood before and after treatment were detected by enzyme-linked immunosorbent assay (ELISA). Results BDNF levels in both groups after treatment were significantly higher than those before treatment (P <0.05). BDNF levels in the exercise group after 14 days of treatment were significantly higher than those in the control group [(101.03 ± 3.34) pg / mg] 68.12 ± 1.41) pg / mg], the difference was statistically significant (P <0.05); BDNF levels in exercise group were higher than those in control group on the 7th and 14th day [(66.17 ± 1.32), (77.15 ± 2.29) pg / mg ], The difference was statistically significant (P <0.05). The effective rate (75.0%) in the control group was significantly lower than that in the exercise group (88.9%), the difference was highly statistically significant (P <0.01). Conclusion Exercise therapy can promote the expression of DBNF and improve the clinical symptoms of patients.