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目的评价紫杉醇联合米托蒽醌治疗难治性晚期乳腺癌疗效。方法 １２例晚期乳腺癌患者术后复发转移，接受常规方案治疗失败后改用 ＴＭｘ方案化疗：第 １ｄ紫杉醇 １３５ ｍｇ／ｍ２，静脉滴注 ４ ｈ；第 ２ ｄ米托葱醒 ８ｍｇ／ｍ２，静脉滴注３０ ｍｉｎ。每４周重复疗程。结果完全缓解（ＣＲ）２例（１６．７％），部分缓解（ＰＲ）７例（５８．３％）。毒副反应主要有白细胞下降。结论 ＴＭｘ方案是治疗难治性晚期乳腺癌疗效较高的方案，值得进一步研究。
Objective To evaluate the efficacy of paclitaxel combined with mitoxantrone in the treatment of refractory advanced breast cancer. Methods Twelve patients with advanced breast cancer recurred and transferred after operation. After receiving the conventional regimen, they were switched to TMx regimen: paclitaxel 135 mg / m2 on day 1 and iv for 4 h; on day 2 Mitoto awake 8 mg / m2, Instillation 30 min. Repeat treatment every 4 weeks. Results Two patients (16.7%) had complete remission (CR) and 7 (58.3%) had partial remission (PR). The main side effects of leukopenia. Conclusion TMx regimen is a highly effective regimen for refractory advanced breast cancer and deserves further study.