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目的：研究纤维蛋白原降解产物的致有丝分裂原活性及一种新型ＰＫＣ抑制剂Ｒｏ３１８２２０（Ｒｏ）的作用．方法：大鼠主动脉平滑肌细胞增殖采用结晶紫染色法测定．结果：纤维蛋白原降解产物促进大鼠主动脉平滑肌细胞的增殖，Ｒｏ（００１－１μｍｏｌ·Ｌ－１）剂量依赖地抑制增殖．结论：Ｒｏ抑制纤维蛋白原降解产物诱导的平滑肌细胞的增殖．
Objective: To study the mitogenic activity of fibrinogen degradation products and the effect of Ro318220 (Ro), a novel PKC inhibitor. Methods: Rat aorta smooth muscle cell proliferation was determined by crystal violet staining. Results: Fibrinogen degradation products promoted the proliferation of aortic smooth muscle cells in rats. Ro (001-1μmol·L-1) inhibited proliferation in a dose-dependent manner. Conclusion: Ro inhibits the proliferation of smooth muscle cells induced by fibrinogen degradation products.