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目的 :研究茶叶中的茶蛋白抵抗电离辐射所引起的突变效应。方法 :Ames试验、V79细胞染色体畸变试验、小鼠嗜多染红细胞 (PCE)微核试验和显性致死试验。结果 :茶蛋白可抵抗60 Co辐射对沙门氏菌的诱变作用 ,降低中国仓鼠肺V79细胞的染色体畸变数 ,使小鼠PCE微核数明显减少 ,对60 Co辐射引起小鼠的显性致死损害有保护作用。结论 :茶蛋白液可防护60 CO辐照所致突变效应 ,可以认为茶蛋白对预防放射治疗时引起的致突变效应有保护作用 ,对茶蛋白用于临床治疗有参考意义。
Objective: To study the mutation effect of tea protein in tea against ionizing radiation. Methods: Ames test, V79 cell chromosome aberration test, mouse polychromatic erythrocyte (PCE) micronucleus test and dominant lethality test. RESULTS: Tea protein could resist the mutagenic effect of 60 Co radiation on Salmonella, reduce the number of chromosomal aberrations in lung V79 cells of Chinese hamster, and significantly reduce the micronuclei of PCE in mice. The dominant lethal damage to mice caused by 60 Co radiation was Protective effects. CONCLUSION: Tea protein solution can protect against the mutation caused by 60Co irradiation. It can be concluded that tea protein has a protective effect on the induction of mutagenicity caused by radiation therapy and has clinical value for the clinical treatment of tea protein.