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【目的】探讨2型糖尿病（T2DM ）患者中性粒细胞与淋巴细胞比值（NLR）与糖尿病视网膜病变（DR）的相关性。【方法】选取T2DM患者202例，其中单纯T2DM患者102例（DM组），合并有DR的T2DM患者100例（DR组），另外选择50名健康体检者为正常对照（NC组）。检测各组白细胞、中性粒细胞、淋巴细胞计数，空腹血糖（FPG）、尿酸及血脂并比较；计算体质量指数（BMI）、NLR。【结果】DR组、DM 组白细胞计数、NLR均显著高于NC组，且DR组NLR高于DM组（均 P＜0．05）。Logistic回归分析显示NLR、病程、收缩压和尿酸是T2DM患者发生DR的危险因素。【结论】NLR与T2DM患者DR的发生密切相关，NLR升高是T2DM患者DR危险因素。“,”[Objective] To explore the association between neutrophil‐lymphocyte ratio (NLR) and diabet‐ic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM ) .[Methods] A total of 202 subjects were recruited ,including 102 T2DM patients without complication (group DM ) and 100 T2DM patients with retinopathy (group DR) as well as 50 normal healthy individuals as controls (group NC) .Height ,weight and blood pressure were measured and recorded .Fasting blood samples were collected for measuring the values of white blood cell count ,neutrophil count ,lymphocyte count ,fasting plasma glucose (FPG) ,uric acid ,blood lipid and glycosylated hemoglobin(HbA1c) .Body mass index (BMI) ,estimated glomerular filtration rate (eG‐FR) and neutrophil‐lymphocyte ratio (NLR) were calculated .The clinical and biochemical parameters were compared among three groups .[Results] The values of white blood cell count and NLR were significantly higher in DR and DM groups than that in NC group .And NLR was higher in DR group than that in DM group ( P <0 .05) .Logistic regression analysis revealed that NLR ,duration of illness ,systemic blood pressure and serum uric acid were risk factors of DR in T 2DM patients (all P<0 .05) .[Conclusion]NLR value is associat‐ed with an onset of DR in T2DM patients .And elevated NLR is an independent risk factor of DR .