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对患者来说疼痛是他们最苦恼的事情。合用药物可通过不同的机制而产生有价值的效果。虽然布洛芬可作为阿司匹林的代用品,但布洛芬超过1200毫克/日时就会增加胃肠副作用的发病率。右丙氧芬(dextroproxyphene)可广泛地与其它止痛药、抗炎药合用以治疗头痛,甚至能减轻癌症疼痛的程度,阿司匹林和右丙氧芬的复合制剂已经使用了很长时间。目前,由400毫克布洛芬和65毫克右丙氧芬的新复合制剂已经制成。为了评价新复合制剂的安全性及其功效,本文曾作以下各项研究:①动物的安全性/毒性研究。②药物动力学研究。③几种一般的实践试验。④功效和生化的安全研究。
Pain is the most distressing thing for the patient. Combinations of drugs can produce valuable results through different mechanisms. Although ibuprofen can be used as a substitute for aspirin, an over 1200 mg / ibuprofen increases the incidence of gastrointestinal side effects. Dextroproxyphene is widely used in combination with other analgesics and anti-inflammatories to treat headache and even reduce the extent of cancer pain. The combination of aspirin and dextro-propofol has been used for a long time. Currently, new complex preparations consisting of 400 mg of ibuprofen and 65 mg of dexketoprofen have been made. In order to evaluate the safety and efficacy of the new compounded formulations, the following studies have been conducted in this paper: (1) Safety / toxicity studies in animals. ② pharmacokinetic studies. ③ several general practice test. ④ efficacy and biochemical safety research.