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目的探讨美托洛尔治疗扩张型心肌病的临床疗效及药理作用。方法选取崇左市人民医院2014年2月—2016年2月收治的扩张型心肌病患者87例,按照随机数字表法将患者分为对照组44例和观察组43例。对照组患者予以常规治疗,观察组患者在常规治疗基础上加用美托洛尔,比较两组患者临床疗效、治疗前后心功能指标[24 h心率、24 h室性期前收缩次数、QT间期离散度(QTd)、左心室射血分数(LVEF)、左心室舒张末期内径(LVEDd)、左心室收缩末期内径(LVESd)]及超敏C反应蛋白(hs-CRP)水平。结果观察组总有效率为97.7%,高于对照组的72.7%(P<0.05)。治疗前两组患者心率、24 h室性期前收缩次数、QTd、LVESd、LVEDd、LVEF、hs-CRP比较,差异无统计学意义(P>0.05);治疗后观察组患者心率、24 h室性期前收缩次数、QTd、LVESd、LVEDd、hs-CRP低于对照组,LVEF高于对照组(P<0.05)。结论采用美托洛尔治疗扩张型心肌病的临床疗效确切,可有效改善患者心功能,降低心肌损伤。
Objective To investigate the clinical efficacy and pharmacological effects of metoprolol in the treatment of dilated cardiomyopathy. Methods Totally 87 patients with dilated cardiomyopathy who were treated in Chongzuo People’s Hospital from February 2014 to February 2016 were divided into control group (44 cases) and observation group (43 cases) according to random number table method. Patients in the control group were treated routinely. Patients in the observation group were treated with metoprolol on the basis of conventional treatment. The clinical effects were compared between the two groups. The cardiac function indexes (24 h heart rate, 24 h premature ventricular contractions, QT (QTd), left ventricular ejection fraction (LVEF), left ventricular end diastolic dimension (LVEDd), left ventricular end systolic diameter (LVESd) and high sensitivity C-reactive protein (hs-CRP) Results The total effective rate in observation group was 97.7%, which was higher than that in control group (72.7%, P <0.05). There was no significant difference in heart rate, 24 h premature ventricular contractions, QTd, LVESd, LVEDd, LVEF and hs-CRP between the two groups before treatment (P> 0.05) The number of contractions before sexual phase, QTd, LVESd, LVEDd, hs-CRP were lower than those in control group, and LVEF was higher than that in control group (P <0.05). Conclusion Metoprolol treatment of dilated cardiomyopathy clinical effect is exact, can effectively improve the patient’s cardiac function, reduce myocardial injury.