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目的观察中西医结合治疗急性早幼粒细胞白血病(APL)的长期疗效。方法 56例APL患者用全反式维甲酸(ATRA)诱导治疗,若白细胞>10.0×109/L,加用亚砷酸(As2O3),完全缓解(CR)后给予4～6个疗程巩固化疗,再予维甲酸、复方黄黛片交替维持治疗2年。结果 56例APL患者,52例(92.8%)达到CR,早期死亡(ED)3例(5.4%)。49例(86.7%)患者接受了诱导缓解后巩固化疗,中位随访50.0(10～133)个月,血液学复发7例(14.3%)。Kaplan-Meier分析5年总生存率85.6%,5年无病生存率81.3%。结论经中西医结合治疗超过80%的APL患者可望获得长期生存。
Objective To observe the long-term efficacy of integrated traditional Chinese and western medicine in the treatment of acute promyelocytic leukemia (APL). Methods A total of 56 cases of APL patients were treated with ATRA. If white blood cell count> 10.0 × 109 / L, arsenic trioxide (As2O3) Then retinoic acid, compound Huangdai film alternately for treatment for 2 years. Results 56 cases of APL patients, 52 cases (92.8%) reached CR, early death (ED) in 3 cases (5.4%). Forty-nine patients (86.7%) received adjuvant chemotherapy after induction, with a median follow-up of 50.0 (10-133) months and 7 hematologic relapse (14.3%). Kaplan-Meier analysis of 5-year overall survival rate 85.6%, 5-year disease-free survival rate of 81.3%. Conclusion The long-term survival of more than 80% APL patients treated by Integrative Chinese and Western medicine is expected.