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利用miRCURY LNATMmicroRNA Arrays 10.0对不明原因复发性自然流产胚胎绒毛和正常胚胎绒毛组织miRNAs进行了检测.结果显示流产绒毛和正常绒毛组织有43个miRNAs存在明显表达差异(ratios≥2.0或ratios≤0.5),其中上调表达33个,下调表达10个.文献检索显示有12个差异表达miRNAs(上调10个,下调2个)已有功能研究报道,主要与细胞侵袭、离子转运和信号转导相关,另外31个尚无功能研究报道.该研究结果提示自然流产绒毛组织中某些差异表达的miRNAs可能与不明原因复发性自然流产的发生有关.
The miRNAs of embryo villus and normal embryo villi of unexplained recurrent spontaneous abortion were detected by using miRCURY LNATM microRNA Arrays 10.0.The results showed that there were 43 miRNAs in aborted and normal villous tissues with significant difference (ratios≥2.0 or ratios≤0.5) Which up-regulated 33, down-regulated 10. The literature search showed that 12 differentially expressed miRNAs (up 10, down 2) have been reported in functional studies, mainly related to cell invasion, ion transport and signal transduction, the other 31 There is no functional study reported.The results suggest that some of the differences in spontaneous abortion villi miRNAs expression may be associated with unexplained recurrent spontaneous abortion.