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目的探讨复方甘草酸苷注射液联合茵栀黄颗粒治疗新生儿肝炎的临床疗效。方法选取2013年3月—2014年3月新乡市妇幼保健院收治的新生儿肝炎患儿30例,随机分为对照组与观察组,各15例。对照组患儿均予以常规综合治疗,观察组患儿在对照组基础上予以复方甘草酸苷注射液联合茵栀黄颗粒治疗。观察两组患者临床疗效、肝功能指标〔总胆红素(TBi L)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)〕变化情况及不良反应发生情况。结果观察组患儿总有效率高于对照组,差异有统计学意义(P<0.05);治疗前两组患儿血清TBi L、ALT、AST水平比较,差异无统计学意义(P>0.05),治疗后观察组患儿血清TBi L、ALT、AST水平低于对照组,差异有统计学意义(P<0.05);两组患儿均未出现严重不良反应。结论复方甘草酸苷注射液联合茵栀黄颗粒治疗新生儿肝炎的临床疗效显著,可促进患儿肝功能恢复,且不良反应少。
Objective To investigate the clinical efficacy of compound glycyrrhizin injection combined with Yinzhihuang granule in the treatment of neonatal hepatitis. Methods Thirty newborns with neonatal hepatitis treated in Xinxiang MCH from March 2013 to March 2014 were randomly divided into control group and observation group, with 15 cases in each group. Children in the control group were given conventional comprehensive treatment. Children in the observation group were given compound glycyrrhizin injection and Yinzhihuang granule on the basis of the control group. The clinical efficacy, indexes of liver function (total bilirubin (TBiL), alanine aminotransferase (ALT) and aspartate aminotransferase (AST)) and the incidence of adverse reactions were observed. Results The total effective rate in the observation group was higher than that in the control group (P <0.05). There was no significant difference in serum TBiL, ALT and AST between the two groups before treatment (P> 0.05) After treatment, the levels of serum TBi L, ALT and AST in the observation group were lower than those in the control group (P <0.05). No serious adverse reactions occurred in both groups. Conclusion Compound glycyrrhizin injection combined with Yinzhihuang granules in the treatment of neonatal hepatitis has a significant clinical effect and can promote the recovery of liver function in children with less adverse reactions.