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患者刘某女30岁,因“癫痫”发作入院治疗,经注射地西泮、苯巴比妥钠等抗癫痫药物控制症状后,改服丙戊酸钠片。口服2d后,出现皮肤瘙痒伴皮肤红斑疹,停用丙戊酸钠后,症状好转,但癫痫复发,继续口服此药,再次出现全身瘙痒症状,全身皮肤点片状红斑疹,突出皮肤表面,压之不褪色,眼睑及面部明显浮肿,体温高达39℃,P 95次·min~(-1), BP 103／75 mmHg。立即停用丙戊酸钠给予甲泼尼龙20 mg静滴,50％葡萄糖注射液20 ml+10％葡萄糖酸钙10 ml缓慢iv,连用2 d并口服西替利嗪10 mg,qd,加用抗生素预防感
Patients with a 30-year-old woman Liu, due to “epilepsy” seizures admission treatment, after the injection of diazepam, phenobarbital and other antiepileptic drugs to control symptoms, change service sodium valproate tablets. Oral 2d, the skin itching with skin erythema, valproate withdrawal, the symptoms improved, but the recurrence of epilepsy and continue oral administration of the drug, itching again appeared systemic symptoms of systemic skin flake rash, highlighting the skin surface, The pressure does not fade, eyelids and facial edema, body temperature up to 39 ℃, P 95 times · min -1, BP 103/75 mmHg. Immediate withdrawal of sodium valproate given intravenous methylprednisolone 20 mg intravenous infusion of 50% glucose 20 ml + 10% calcium gluconate 10 ml slow for 2 d and oral cetirizine 10 mg, qd, plus Antibiotic prophylaxis