论文部分内容阅读
目前广泛地利用传统的体细胞衰老理论和方法对成体干细胞衰老进行研究,忽视了成体干细胞特有的自我更新功能和相应的干性基因的作用.干性基因的下调可能是导致间充质干细胞衰老的主要原因.通过查阅相关资料发现主要干性基因与衰老相关基因表达水平的相互拮抗关系,这体现在以下4个方面:a.干细胞衰老伴随着干性基因的下调;b.干性基因表达抑制细胞的衰老;c.干性基因抑制衰老相关基因的表达;d.抑制衰老相关基因促进干性基因的表达.干性基因与衰老相关基因的表达水平存在相互拮抗关系,这为成体干细胞衰老可能源于成体干细胞的干性降低的观点提供了坚实的分子基础.
Currently, the theory and method of somatic cell aging are extensively used to study the aging of adult stem cells, ignoring the self-renewal function of adult stem cells and the function of corresponding dry genes. The down-regulation of dry genes may result in the aging of mesenchymal stem cells The main reason for this is that the correlation between the major dry-related genes and the expression of senescence-related genes is found in the following four aspects: a. Stem cell aging is accompanied by down-regulation of dry genes; b. Inhibition of cell senescence; c. Gene suppression of senescence-related genes by dry genes; d. Inhibition of senescence-related genes and promotion of expression of dry genes. Expression of senescence-associated genes is correlated with each other. Antagonism of senescence- It may provide a solid molecular basis that stems from the dry reduction of adult stem cells.