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目的:观察沙美特罗替卡松治疗感染后咳嗽的临床效果及其不良反应,为临床治疗感染后咳嗽提供依据。方法:感染后咳嗽患者324例随机分为对照组和观察组各162例。对照组给予常规治疗,观察组在常规治疗基础上应用沙美特罗替卡松吸入治疗。评估患者治疗前后日间、夜间咳嗽症状评分,记录患者症状消失时间,应用视觉模拟评分评估咳嗽严重程度。观察两组患者在治疗期间出现的不良反应。结果:治疗后,两组日间、夜间症状评分和视觉模拟评分均较前明显降低(P<0.05),且观察组各项评分均优于对照组(P<0.05)。观察组症状消失时间明显短于对照组(P<0.05)。两组药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论:沙美特罗替卡松治疗感染后咳嗽具有较好的临床疗效,能够显著改善患者临床症状,缩短症状改善时间,安全性较好,值得临床推广应用。
Objective: To observe the clinical efficacy and adverse reactions of salmeterol and fluticasone in the treatment of post-infection cough, and provide evidence for the clinical treatment of post-infection cough. Methods: 324 patients with cough after infection were randomly divided into control group and observation group of 162 cases. The control group was given routine treatment. The observation group was treated with salmeterol and fluticasone inhalation on the basis of routine treatment. Patients were assessed before and after treatment day and night cough score, record the patient’s symptoms disappear time, visual analog scale assessment of cough severity. Adverse reactions were observed during treatment in both groups. Results: After treatment, the symptom scores and visual analogue scores of daytime and nighttime in both groups were significantly lower than before (P <0.05), and all the scores in the observation group were better than those in the control group (P <0.05). Observation group symptoms disappeared significantly shorter than the control group (P <0.05). There was no significant difference between the two groups in the incidence of adverse drug reactions (P> 0.05). Conclusion: Salmeterol and ticagastrone have better clinical efficacy in treating cough after infection, which can significantly improve clinical symptoms and shorten the time of symptom improvement, which is safe and worthy of clinical application.