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目的：探讨周围型肺癌ＣＴ强化与微血管密度（ＭＶＤ）的关系，以提高对肺结节的鉴别诊断能力。材料和方法：对４０例周围型肺癌（鳞癌 １８例，腺癌 ２２例）应用非离子型造影剂进行动态 ＣＴ扫描（剂量 １．５ｍｌ／ ｋｇ体重，流速３ｍｌ／ｓ，分别在注射后０．５，１，２，３，４ｍｉｎ扫描）并测量ＣＴ值，肺癌标本进行微血管密度测定，并比较肺癌增强模式和最大增强幅度与微血管密度的关系。结果：４０例肺癌平均强化值为 ５０．６５± １９．５９Ｈｕ，峰值在注射造影剂后１ｍｉｎ。腺癌与鳞癌的增强幅度无显著性差异（分别为５３．４５±２３．２２Ｈｕ及４７．２２±１４．６３Ｈｕ，Ｐ＞０．０５），而腺癌的ＭＶＤ明显低于鳞癌（分别为４５．１１±１１．２５和６１．４４±９．９１，Ｐ＜０．０５）。肺癌ＣＴ强化值与微血管密度呈正相关（ｒ＝０．８８７４，Ｐ＜０．００１）。结论：肺癌ＣＴ增强的幅度及模式与其血供及微血管密度有关，动态增强可以反映肺癌的强化特征，有助于诊断。
Objective: To investigate the relationship between CT enhancement and microvessel density (MVD) in peripheral lung cancer to improve the differential diagnosis of lung nodules. Materials and Methods: Forty patients with peripheral lung cancer (18 cases of squamous cell carcinoma and 22 cases of adenocarcinoma) were subjected to dynamic CT scan with a non-ionic contrast agent (dose 1.5 ml/kg body weight, flow rate 3 ml/s, respectively 0 after injection .5,1,2,3,4 min scan) and CT values were measured, and microvessel density measurements were performed on lung cancer specimens. The relationship between the enhanced pattern of lung cancer and the maximum enhancement amplitude and microvessel density was compared. Results: The average enhancement value of 40 cases of lung cancer was 50.65±19.59Hu. The peak value was 1min after injection of contrast agent. There was no significant difference in the enhancement amplitude between adenocarcinoma and squamous cell carcinoma (53.45±23.22Hu and 47.22±14.63Hu, respectively, P>0.05), while the MVD of adenocarcinoma was significantly lower than that of squamous cell carcinoma (respectively. 45.11±11.25 and 61.44±9.91, P<0.05). The CT enhancement value of lung cancer was positively correlated with microvessel density (r=0.8874, P<0.001). Conclusion: The amplitude and pattern of CT enhancement in lung cancer are related to blood supply and microvessel density. Dynamic enhancement can reflect the enhanced characteristics of lung cancer and is helpful for diagnosis.